缪志江

作者: 时间:2022-03-04

缪志江 博士

讲师

一、 工作学习经历

2010-2014 云南师范大学生物技术专业,理学学士

2014-2017 4066金沙生物化学与分子生物学专业,理学硕士

2017-2021 荷兰鹿特丹大学伊拉斯姆斯医学研究中心(Erasmus Medical Center),病原生物学,理学博士

2021-至今 4066金沙(中国)有限公司,讲师(第五类高层次引进人才)

二、 研究领域

丁型肝炎病毒(hepatitis delta virus, HDV)是目前已知的可感染人类的最小的RNA病毒。HDV属于乙型肝炎病毒(hepatitis B virus, HBV)的卫星病毒,其病毒颗粒由HDV基因组(含~1700个核苷酸组成的单股负链的环状RNA)、HDV抗原蛋白(HDAg)和HBV表面抗原蛋白(HBsAg)共同组成。由于HDV本身具有缺陷性,所以其只能依靠HBV进行增值(主要包括病毒颗粒组装、释放及入胞等过程)并通过与HBV合并感染的方式进行传播。虽然HDV是一种缺陷病毒,但它与HBV合并感染会急剧加速肝硬化病程并增加肝癌发生的风险,从而导致最严重的肝炎疾病,严重危害人类健康及人民生命财产安全。因此,HDV议题正成为肝病学研究领域中继HBV和HCV之后的另一个重要新兴热点。为此,我们的研究首先靶向HDV分子流行病学,并在此研究成果基础上进一步开展HDV细胞模型、病理机制和治疗药物筛选研发等相关课题,最终旨在建立一套关于HDV“防-控-研-治”的完整疾病防治及科研体系。此外,HDV作为一种重要的病毒模型,其本身的病毒学和生物学等相关问题也具有极大研究价值和意义,值得我们进一步深入研究探索。

三、 开设的课程

暂无。

四、 学术任职情况

1、Liver International杂志审稿人(IF=5.8; JCR Q1区/胃肠肝病学二区);

2、AIDS research and human retroviruses杂志审稿人(IF=2.2; JCR Q4区/病毒学四区)。

五、 代表性论文

1. Zhijiang Miao1, Zhenrong Xie1, Li Ren, Qiuwei Pan*. Combating hepatitis D: advances and challenges,Chinese Medical Journal, 2021 (Invited Review, in print). (IF=2.6; JCR Q3/医学三区)

2. Ziqin Dian, Yi Sun, Guiqian Zhang, Ya Xu, Xin Fan, Xuemei Yang, Qiuwei Pan, Maikel Peppelenbosch andZhijiang Miao*. Rotavirus-related systemic diseases: clinical manifestation, evidence and pathogenesis,Critical Reviews in Microbiology, 2021.(IF=7.6; JCR Q1区/微生物学二区)

3. Zhijiang Miao, Ruyi Zhang, Peifa Yu, Yang Li, Qiuwei Pan* and Yunlong Li*. The macrolide antibiotic azithromycin potently inhibits hepatitis E virus in cell culture models,International Journal of Antimicrobial Agents, 2021. (IF=5.3; JCR Q1医学二区)

4. Zhijiang Miaoand Qiuwei Pan*. Revisiting the estimation of hepatitis D global prevalence,Journal of Hepatology, 2020.(Letter, IF=25.1; JCR Q1区/胃肠肝病学一区Top)

5. Zhijiang Miao, Shaoshi Zhang, Xumin Ou, Shan Li, Zhongren Ma, Wenshi Wang, Maikel P Peppelenbosch, Jiaye Liu* and Qiuwei Pan*, Estimating the Global Prevalence, Disease Progression, and Clinical Outcome of Hepatitis Delta Virus Infection.Journal of Infectious Diseases, 2019.(IF=5.2; JCR Q1区/医学二区Top)

6. Zhijiang Miao, Shaoshi Zhang, Zhongren Ma, Mohamad S. Hakim, Wenshi Wang, Maikel P. Peppelenbosch and Qiuwei Pan*, Recombinant identification, molecular classification and proposed reference genomes for hepatitis delta virus,Journal of Viral Hepatitis, 2018.(IF=3.7; JCR Q2区/病毒学二区)

7. Zhijiang Miao, Yunlong Li, Peifa Yu, Bingting Yu, Maikel P. Peppelenbosch and Qiuwei Pan*, The dynamics of hepatitis delta virus prevalence and its potential association with hepatitis B virus vaccination,Clinics and Research in Hepatology and Gastroenterology, 2021.(IF=2.9; JCR Q3区/胃肠肝病学四区)

8. Zhijiang Miao1, Li Gao1, Yindi Song, Ming Yang, Mi Zhang, Jincheng Lou, Yue Zhao, Xicheng Wang, Yue Feng*, Xingqi Dong* and Xueshan Xia*. Prevalence and clinical impact of human pegivirus-1 infection in HIV-1-infected individuals in Yunnan, China.Viruses, 2017.(IF=5.0; JCR Q2区/病毒学三区)

9. Zhijiang Miao1, Zhenrong Xie1, Jing Miao, Jieyu Ran, Yue Feng* and Xueshan Xia*, Regulated Entry of Hepatitis C Virus into Hepatocytes.Viruses, 2017.(IF=5.0; JCR Q2区/病毒学三区)

10. Peifa Yu,Zhijiang Miao, Yang Li, Maikel P. Peppelenbosch, Qiuwei Pan*. cGAS-STING Effectively Restricts Murine Norovirus Infection But Antagonizes the Antiviral Action of N-terminus of RIG-I in Mouse Macrophages.Gut Microbes, 2021. (IF=10.2; JCR Q1区/医学一区Top)

11. Yunlong Li,Zhijiang Miao, Pengfei Li, Ruyi Zhang , Denis E Kainov , Zhongren Ma , Robert A de Man, Maikel P Peppelenbosch and Qiuwei Pan*, Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importinα1.Archives of Virology, 2021.(IF=2.6; JCR Q3区/病毒学四区)

12. Ling Wang, Jiaye Liu,Zhijiang Miao, Qiuwei Pan* and Wanlu Cao*. Lipid droplets and their interactions with other organelles in liver diseases.The International Journal of Biochemistry & Cell Biology,2021.(IF=5.1; JCR Q2区/细胞生物学三区)

13. Peifa Yu, Yang Li, Yunlong Li,Zhijiang Miao, Maikel P. Peppelenbosch and Qiuwei Pan*. Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.Journal of Biological Chemistry, 2020.(IF=5.2; JCR Q2区/生物学二区Top)

14. Peifa Yu, Yang Li, Yunlong Li,Zhijiang Miao, Yining Wang, Maikel P. Peppelenbosch and Qiuwei Pan*. Murine norovirus replicase augments RIG-I-like receptors-mediated antiviral interferon response.Antiviral Research, 2020.(IF=6.0; JCR Q1/2区/病毒学药学二区)

15. Xumin Ou, Buyun Ma, Ruyi Zhang,Zhijiang Miao, Anchun Cheng, Maikel P. Peppelenbosch and Qiuwei Pan*. A simplified qPCR method revealing tRNAome remodeling upon infection by genotype 3 hepatitis E virus.FEBS letters, 2020.(IF=4.1; JCR Q3区/病毒学四区)

16. Yindi Song1, Yue Feng1,Zhijiang Miao, Binghui Wang, Ming Yang, A-Mei Zhang, Li Liu and Xueshan Xia*. Near-Full- Length Genome Sequences of a Novel Hiv-1 Circulating Recombinant Form, Crf01_Ae/B'/C(Crf78_Cpx), in Yunnan, China.AIDS research and human retroviruses, 2016.(IF=2.2; JCR Q4区/病毒学四区)

17. Yanping Li1, Jing Miao1,Zhijiang Miao, Yindi Song, Min Wen, Ya Zhang, Shimin Guo, Yuan Zhao, Yue Feng* and Xueshan Xia*. Identification of a Novel HIV Type 1 Circulating Recombinant Form(CRF86_BC)Among Heterosexuals in Yunnan, China.AIDS research and human retroviruses, 2016.(IF=2.2; JCR Q4区/病毒学四区)

18. Li Ren, Binghui Wang,Zhijiang Miao, Pan Liu, Shiyi Zhou, Yun Feng, Shuting Yang, Xueshan Xia* and Kunhua Wang*, A correlation analysis of HHV infection and its predictive factors in an HIV-seropositive population in Yunnan, China,Journal of Medical virology, 2019.(IF=2.3; JCR Q4区/病毒学四区)

五、 主持项目

1、国家自然科学研究基金资助项目,82060608,云南省丁型肝炎病毒分子流行病学及其演化变异规律研究,2021/01-2024/12,35万元,进行中,指导并参与;

2、云南省昆明市呈贡区2020年人才工作项目,YNJH-2019,丁型肝炎病毒核酸检测新技术研发团队建设,2020/04-2021/04,8万元,已结题,指导并参与;

3、云南省2020年应用基础研究计划项目,008156678056,HPgV-2遗传变异规律及基因型分类系统研究,2021/06-2024/05,10万元,进行中,指导并参与。

六、 联系方式

地址:昆明市呈贡区4066金沙(中国)有限公司(650500)

电话:0871-65916005

E-mail:miaozhijiang@yeah.net

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