陈浩 博士
讲师
一、 工作学习经历
2004-2008 西南交通大学中药学专业，理学学士
2009-2014 中科院昆明植物研究所药物化学专业，理学博士
2014-2016 康龙化成(北京)新药技术股份有限公司，课题组长
2016-2021 中山大学药学院，博士后
2021-至今 4066金沙(中国)有限公司，讲师
二、 研究领域
小分子与大分子作用计算化学研究；基于机器学习发现、优化抗病毒小分子、神经系统和代谢系统疾病的治疗药物、探针：将机器学习、分子模拟、荧光偏振及SPR高通量筛选等技术模块化，发现、优化新骨架分子，进行创新药物研发。
三、 教学课程
《基础有机化学》
四、 代表性论文
1. Chen Hao#; Chen Ziyang#; Zhang Zizhen#; Li Yali; Zhang Shushu; Jiang Fuqiang; Wei Junkang; Ding Peng; Zhou Huihao*; Gu Qiong*; Xu Jun*; Discovery of new LXRβ agonists as glioblastoma inhibitors,European Journal of Medicinal Chemistry,2020, 194: 112240.
2. Chen Ziyang#;Chen Hao#; Zhang Zizhen; Ding Peng; Yan Xin; Li Yanwen; Zhang Songxuan; Gu Qiong; Zhou Huihao*; Xu Jun*; Discovery of novel liver X receptor inverse agonists as lipogenesis inhibitors,European Journal of Medicinal Chemistry,2020, 206: 112793.
3. Li Chanjuan#;Chen Hao#; Chen Xinying; Li Yanwen; Hua Pei; Wei Junkang; Song Ching; Gu Qiong; Zhou Huihao; Zhang Jingxia*; Xu Jun*; Discovery of tissue selective liver X receptor agonists for the treatment of atherosclerosis without causing hepatic lipogenesis,European Journal of Medicinal Chemistry, 2019, 182: 11647.
4. Zhang Zizhen#;Chen Hao#; Chen Ziyang; Ding Peng; Ju Yingchen; Gu Qiong; Xu Jun; Zhou Huihao*; Identify liver X receptor beta modulator building blocks by developing a fluorescence polarization-based competition assay,European Journal of Medicinal Chemistry, 2019, 178: 458-467.
5. Cheng Yanfang; Yin Zhiyong; Jiang Fuqiang; Xu Jun;Chen Hao*; Gu Qiong*; Two new lignans from the aerial parts ofSaururus chinensiswith cytotoxicity toward nasopharyngeal carcinoma.Fitoterapia, 2020, 141: 104344.
6. Yin Zhiyong; Cheng Yanfang; Wei Junkang; Luo Xiangkun; Luo Pan; Liu Shaonan; Xu Jun;Chen Hao*; Gu Qiong*; Chemical constituents fromDaphne tanguticaand their cytotoxicity against nasopharyngeal carcinoma cells.Fitoterapia, 2018, 130: 105-111.
7. Chen Hao#, Ma Yunbao, Huang Xiaoyan, Geng Changan, Zhao Yong, Wang Lijun, Guo Ruihua, Liang Wenjuan, Zhang Xuemei, Chen Jijun*. Synthesis, structure-activity relationships and biological evaluation ofdehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents.Bioorganic & Medicinal Chemistry Letters, 2014, 24, 2353-2359.
8. Chen Hao#, Wang Lijun, Ma Yunbao, Huang Xiaoyan, Geng Changan, Zhang Xuemei, Chen Jijun*.Panaxadiol and panaxatriol derivatives as anti-hepatitis B virus inhibitors.NaturalProducts and Bioprospecting，2014,4(3), 163-174.
五、 主持项目
1. 云南省基础研究计划面上项目，202101AT070223,薄荷烷型FXR激动剂的设计优化和抗HBV活性研究
六、 联系方式
地址：昆明市呈贡区4066金沙(中国)有限公司（650500）
电话：0871-65920253
E-mail：Chenhao@kust.edu.cn
